Arizona Cardinals loss to San Francisco 49ers Nov 21, 2022; Mexico City, MEXICO; Arizona Cardinals quarterback Colt McCoy (12) is tackled by San Francisco 49ers linebacker Fred Warner (54) during the first half at Estadio Azteca. Mandatory Credit: Kirby Lee-USA TODAY Sports

The Arizona Cardinals came into their Monday Night Football game against the San Francisco 49ers desperately needing a victory.

Pregame injury reports already put Arizona at a significant disadvantage in the game, with star quarterback Kyler Murray being ruled out.

With their backs against the wall, the Cardinals laid a complete egg in the matchup against the 49ers.

San Francisco quarterback Jimmy Garoppolo had a season-best performance, throwing for 228 yards along with four passing touchdowns.

It was a laughable performance on defense for the Cardinals, which ESPN commentator Troy Aikman detailed on Garoppolo’s final touchdown pass of the game to star tight end George Kittle.

“This is embarrassing for the Arizona Cardinals,” said Aikman. “Antonio Hamilton doesn’t even come up after all the tackles he made last week and even try to make an attempt on George Kittle… They’re a losing football team, and they’re playing like one on that play.”

Meanwhile the Cardinals’ offense also struggled mightily without Murray, only scoring 10 points offensively in the game with backup quarterback Colt McCoy at the helm.

It was a night that the Arizona Cardinals and head coach Kliff Kingsbury would love to forget, and many took the chance to blast the organization on social media for their no-show on Monday night.

This loss puts the Cardinals down to 4-7 on the year, and it appears that people are now calling for Kingsbury to potentially lose his job.

It’s difficult to see the Arizona Cardinals bouncing back from this kind of beatdown from the 49ers, but they will get the opportunity to do so next week against the Los Angeles Chargers.

About Reice Shipley

Reice Shipley is a staff writer for Comeback Media that graduated from Ithaca College with a degree in Sports Media. He previously worked at Barrett Sports Media and is a fan of all things Syracuse sports.