Patrick Mahomes Justin Herbert

The Kansas City Chiefs held off the Los Angeles Chargers 27-24 in the Amazon Prime Video (regular-season) debut of Thursday Night Football, and in an AFC West clash featuring two Super Bowl contenders.

The game-changing play came during a 17-17 tie in the fourth quarter when Kansas City seventh-round rookie Jaylen Watson intercepted a Justin Herbert pass on first-and-goal and took it all the way back for a 99-yard pick-six.

Later, with Kansas City up 27-17, it appeared that Herbert may be done for the game after taking a big hit to the ribs.

Herbert left the game for one play (replaced by Chase Daniel) but returned and played through injury (the Chargers provided an update on Herbert’s injury status after the game). It was clearly bothering Herbert and prevented him from running for an easy first down one play, but then he followed it up with an incredible dime on fourth down.

And later on the drive, Herbert threw a touchdown pass to Joshua Palmer to make it a one-score game.

Against most teams and quarterbacks, Herbert — who completed 33-of-48 passes for 334 yards, three touchdowns, one interception, and a 100.5 passer rating — would’ve come out on the winning end in a very admirable effort.

But, Herbert was facing another superstar quarterback in Patrick Mahomes, who completed 24-of-35 passes for 235 yards, two touchdowns, no interceptions, and a 106.2 passer rating. Mahomes showed off his otherworldly, magical skills on the touchdown passes.

The Chiefs overcame a 10-0 deficit and didn’t score until 11:38 remained in the second quarter.

The game also featured an incredible Mike Williams touchdown catch, Derwin James going full WWE on Travis Kelce, and the Chargers getting a backdoor cover.

This is likely one of the many entertaining, competitive battles we’ll see between Mahomes and Herbert in the future. They’ll face each other again on Nov. 20 in Los Angeles, and maybe they’ll meet in the AFC playoffs as well. And they could be a battle all season long for the AFC West title.

But, for the Chargers to contend for the AFC West title, Herbert will need to be healthy. He’s getting x-rays on Thursday night.

Here’s a look at how the NFL world is reacting to the Chiefs’ win and the main storylines from Thursday Night Football:

About Matt Clapp

Matt is an editor at The Comeback. He attended Colorado State University, wishes he was Saved by the Bell's Zack Morris, and idolizes Larry David. And loves pizza and dogs because obviously.

He can be followed on Twitter at @Matt2Clapp (also @TheBlogfines for Cubs/MLB tweets and @DaBearNecess for Bears/NFL tweets), and can be reached by email at mclapp@thecomeback.com.